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Structural mimicry in bacterial virulence

Author

Listed:
  • C. Erec Stebbins

    (Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine)

  • Jorge E. Galán

    (Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine)

Abstract

An important mechanism underlying the strategies used by microbial pathogens to manipulate cellular functions is that of functional mimicry of host activities. In some cases, mimicry is achieved through virulence factors that are direct homologues of host proteins. In others, convergent evolution has produced new effectors that, although having no obvious amino-acid sequence similarity to host factors, are revealed by structural studies to display mimicry at the molecular level.

Suggested Citation

  • C. Erec Stebbins & Jorge E. Galán, 2001. "Structural mimicry in bacterial virulence," Nature, Nature, vol. 412(6848), pages 701-705, August.
    • Handle: RePEc:nat:nature:v:412:y:2001:i:6848:d:10.1038_35089000
    DOI: 10.1038/35089000
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    Cited by:

    1. Nan Zhao & Bin Pang & Chi-Ren Shyu & Dmitry Korkin, 2011. "Structural Similarity and Classification of Protein Interaction Interfaces," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-14, May.

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