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Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

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  • Jonathan T. Eggenschwiler

    (Molecular Biology Program, Sloan-Kettering Institute)

  • Edward Espinoza

    (Molecular Biology Program, Sloan-Kettering Institute)

  • Kathryn V. Anderson

    (Molecular Biology Program, Sloan-Kettering Institute)

Abstract

The mouse open brain (opb) and Sonic hedgehog (Shh) genes have opposing roles in neural patterning: opb is required for dorsal cell types and Shh is required for ventral cell types in the spinal cord1,2,3. Here we show that opb acts downstream of Shh. Ventral cell types that are absent in Shh mutants, including the floor plate, are present in Shh opb double mutants. The organization of ventral cell types in Shh opb double mutants reveals that Shh-independent mechanisms can pattern the neural tube along its dorsal–ventral axis. We cloned opb by a map-based approach and found that it encodes Rab23, a member of the Rab family of vesicle transport proteins. The data indicate that dorsalizing signals activate transcription of Rab23 in order to silence the Shh pathway in dorsal neural cells.

Suggested Citation

  • Jonathan T. Eggenschwiler & Edward Espinoza & Kathryn V. Anderson, 2001. "Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway," Nature, Nature, vol. 412(6843), pages 194-198, July.
    • Handle: RePEc:nat:nature:v:412:y:2001:i:6843:d:10.1038_35084089
    DOI: 10.1038/35084089
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    Cited by:

    1. Maria E Gallegos & Sanjeev Balakrishnan & Priya Chandramouli & Shaily Arora & Aruna Azameera & Anitha Babushekar & Emilee Bargoma & Abdulmalik Bokhari & Siva Kumari Chava & Pranti Das & Meetali Desai , 2012. "The C. elegans Rab Family: Identification, Classification and Toolkit Construction," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-19, November.

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