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Analysis of oral polio vaccine CHAT stocks

Author

Listed:
  • N. Berry

    (Division of Retrovirology)

  • C. Davis

    (Division of Retrovirology)

  • A. Jenkins

    (Division of Retrovirology)

  • D. Wood

    (Division of Virology)

  • P. Minor

    (Division of Virology)

  • G. Schild

    (National Institute for Biological Standards and Control)

  • M. Bottiger

    (Karolinska Institute)

  • H. Holmes

    (Division of Retrovirology)

  • N. Almond

    (Division of Retrovirology)

Abstract

Batches of experimental oral vaccines against poliovirus (OPV CHAT) that were administered in Central Africa in the 1950s have been implicated in the origin of the AIDS pandemic because of possible retroviral contamination during the vaccine's manufacture, which allegedly involved chimpanzee kidney cells1. Here we use a molecular analysis to show that two CHAT type-1 polio vaccine stocks were prepared from macaque and not chimpanzee cells, and contain neither human nor simian immunodeficiency virus sequences. Our results do not support the hypothesis that these materials were responsible for the transmission of the AIDS virus to humans.

Suggested Citation

  • N. Berry & C. Davis & A. Jenkins & D. Wood & P. Minor & G. Schild & M. Bottiger & H. Holmes & N. Almond, 2001. "Analysis of oral polio vaccine CHAT stocks," Nature, Nature, vol. 410(6832), pages 1046-1047, April.
    • Handle: RePEc:nat:nature:v:410:y:2001:i:6832:d:10.1038_35074176
    DOI: 10.1038/35074176
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