IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v410y2001i6831d10.1038_35073648.html
   My bibliography  Save this article

The dynamics of CD4+ T-cell depletion in HIV disease

Author

Listed:
  • Joseph M. McCune

    (Gladstone Institute of Virology and Immunology, University of California at San Francisco)

Abstract

The size and composition of the CD4+ T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4+ T cells are instead depleted. Such depletion cannot result simply from accelerated destruction of mature CD4+ T cells — sources of T-cell production must also fail. Ironically, this failure may be precipitated by physiological mechanisms designed to maintain homeostasis in the face of accelerated T-cell loss.

Suggested Citation

  • Joseph M. McCune, 2001. "The dynamics of CD4+ T-cell depletion in HIV disease," Nature, Nature, vol. 410(6831), pages 974-979, April.
    • Handle: RePEc:nat:nature:v:410:y:2001:i:6831:d:10.1038_35073648
    DOI: 10.1038/35073648
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35073648
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35073648?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Julia Drylewicz & Nienke Vrisekoop & Tendai Mugwagwa & Anne Bregje de Boer & Sigrid A Otto & Mette D Hazenberg & Kiki Tesselaar & Rob J de Boer & José A M Borghans, 2016. "Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-12, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:410:y:2001:i:6831:d:10.1038_35073648. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.