IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v410y2001i6829d10.1038_35070587.html
   My bibliography  Save this article

Bone marrow cells regenerate infarcted myocardium

Author

Listed:
  • Donald Orlic

    (Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI)

  • Jan Kajstura

    (New York Medical College)

  • Stefano Chimenti

    (New York Medical College)

  • Igor Jakoniuk

    (New York Medical College)

  • Stacie M. Anderson

    (Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI)

  • Baosheng Li

    (New York Medical College)

  • James Pickel

    (Laboratory of Molecular Biology, NINDS, NIH)

  • Ronald McKay

    (Laboratory of Molecular Biology, NINDS, NIH)

  • Bernardo Nadal-Ginard

    (New York Medical College)

  • David M. Bodine

    (Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI)

  • Annarosa Leri

    (New York Medical College)

  • Piero Anversa

    (New York Medical College)

Abstract

Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time1. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation2,3,4,5; these events promote structural and functional repair6,7,8. This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice. We sorted lineage-negative (Lin-) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein9 by fluorescence-activated cell sorting on the basis of c-kit expression10. Shortly after coronary ligation, Lin- c-kit POS cells were injected in the contracting wall bordering the infarct. Here we report that newly formed myocardium occupied 68% of the infarcted portion of the ventricle 9?days after transplanting the bone marrow cells. The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.

Suggested Citation

  • Donald Orlic & Jan Kajstura & Stefano Chimenti & Igor Jakoniuk & Stacie M. Anderson & Baosheng Li & James Pickel & Ronald McKay & Bernardo Nadal-Ginard & David M. Bodine & Annarosa Leri & Piero Anvers, 2001. "Bone marrow cells regenerate infarcted myocardium," Nature, Nature, vol. 410(6829), pages 701-705, April.
    • Handle: RePEc:nat:nature:v:410:y:2001:i:6829:d:10.1038_35070587
    DOI: 10.1038/35070587
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35070587
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35070587?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nanako Kawaguchi & Andrew J Smith & Cheryl D Waring & Md Kamrul Hasan & Shinka Miyamoto & Rumiko Matsuoka & Georgina M Ellison, 2010. "c-kitpos GATA-4 High Rat Cardiac Stem Cells Foster Adult Cardiomyocyte Survival through IGF-1 Paracrine Signalling," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-14, December.
    2. Ling-Li Li & Guohua Ding & Nan Feng & Ming-Huang Wang & Yuh-Shan Ho, 2009. "Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006," Scientometrics, Springer;Akadémiai Kiadó, vol. 80(1), pages 39-58, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:410:y:2001:i:6829:d:10.1038_35070587. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.