IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v410y2001i6826d10.1038_35066602.html
   My bibliography  Save this article

Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA

Author

Listed:
  • Aisha Siddiqa

    (Box 178, The University of Texas M. D. Anderson Cancer Center)

  • Jennifer C. Sims-Mourtada

    (Box 178, The University of Texas M. D. Anderson Cancer Center)

  • Liliana Guzman-Rojas

    (Box 178, The University of Texas M. D. Anderson Cancer Center)

  • Roberto Rangel

    (Box 178, The University of Texas M. D. Anderson Cancer Center)

  • Christiane Guret

    (Laboratory for Immunology Research, Schering-Plough)

  • Vicente Madrid-Marina

    (Centro de Investigacion Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica)

  • Yan Sun

    (Box 178, The University of Texas M. D. Anderson Cancer Center)

  • Hector Martinez-Valdez

    (Box 178, The University of Texas M. D. Anderson Cancer Center)

Abstract

Proteins containing AT hooks bind A/T-rich DNA through a nine-amino-acid motif and are thought to co-regulate transcription by modifying the architecture of DNA, thereby enhancing the accessibility of promoters to transcription factors1,2. Here we describe AKNA, a human AT-hook protein that directly binds the A/T-rich regulatory elements of the promoters of CD40 and CD40 ligand (CD40L) and coordinately regulates their expression. Consistent with its function, AKNA is a nuclear protein that contains multiple PEST protein-cleavage motifs, which are common in regulatory proteins with high turnover rates3. AKNA is mainly expressed by B and T lymphocytes, natural killer cells and dendritic cells. During B-lymphocyte differentiation, AKNA is mainly expressed by germinal centre B lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation4,5,6,7,8,9,10,11,12. Our findings show that an AT-hook molecule can coordinately regulate the expression of a key receptor and its ligand, and point towards a molecular mechanism that explains homotypic cell interactions.

Suggested Citation

  • Aisha Siddiqa & Jennifer C. Sims-Mourtada & Liliana Guzman-Rojas & Roberto Rangel & Christiane Guret & Vicente Madrid-Marina & Yan Sun & Hector Martinez-Valdez, 2001. "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA," Nature, Nature, vol. 410(6826), pages 383-387, March.
    • Handle: RePEc:nat:nature:v:410:y:2001:i:6826:d:10.1038_35066602
    DOI: 10.1038/35066602
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35066602
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35066602?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wei Xu & Ines Mesa-Eguiagaray & David M. Morris & Chengjia Wang & Calum D. Gray & Samuel Sjöström & Giorgos Papanastasiou & Sammy Badr & Julien Paccou & Xue Li & Paul R. H. J. Timmers & Maria Timofeev, 2025. "Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank," Nature Communications, Nature, vol. 16(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:410:y:2001:i:6826:d:10.1038_35066602. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.