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Identification of CRE1 as a cytokinin receptor from Arabidopsis

Author

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  • Tsutomu Inoue

    (Graduate School of Science, Osaka University,Toyonaka)

  • Masayuki Higuchi

    (Graduate School of Science, Osaka University,Toyonaka)

  • Yukari Hashimoto

    (Graduate School of Science, Osaka University,Toyonaka)

  • Motoaki Seki

    (Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute)

  • Masatomo Kobayashi

    (Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute)

  • Tomohiko Kato

    (Kazusa DNA Research Institute, Kisarazu)

  • Satoshi Tabata

    (Kazusa DNA Research Institute, Kisarazu)

  • Kazuo Shinozaki

    (Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute)

  • Tatsuo Kakimoto

    (Graduate School of Science, Osaka University,Toyonaka)

Abstract

Cytokinins are a class of plant hormones that are central to the regulation of cell division and differentiation in plants1,2. It has been proposed that they are detected by a two-component system, because overexpression of the histidine kinase gene CKI1 induces typical cytokinin responses3 and genes for a set of response regulators of two-component systems can be induced by cytokinins4,5. Two-component systems use a histidine kinase as an environmental sensor and rely on a phosphorelay for signal transduction. They are common in microorganisms, and are also emerging as important signal detection routes in plants6,7,8,9. Here we report the identification of a cytokinin receptor. We identified Arabidopsis cre1 (cytokinin response 1) mutants, which exhibited reduced responses to cytokinins. The mutated gene CRE1 encodes a histidine kinase. CRE1 expression conferred a cytokinin-dependent growth phenotype on a yeast mutant that lacked the endogenous histidine kinase SLN1 (ref. 10), providing direct evidence that CRE1 is a cytokinin receptor. We also provide evidence that cytokinins can activate CRE1 to initiate phosphorelay signalling.

Suggested Citation

  • Tsutomu Inoue & Masayuki Higuchi & Yukari Hashimoto & Motoaki Seki & Masatomo Kobayashi & Tomohiko Kato & Satoshi Tabata & Kazuo Shinozaki & Tatsuo Kakimoto, 2001. "Identification of CRE1 as a cytokinin receptor from Arabidopsis," Nature, Nature, vol. 409(6823), pages 1060-1063, February.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6823:d:10.1038_35059117
    DOI: 10.1038/35059117
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