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The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X

Author

Listed:
  • D. R. Bentley

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • P. Deloukas

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. Dunham

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • L. French

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. G. Gregory

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. J. Humphray

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. J. Mungall

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • M. T. Ross

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • N. P. Carter

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • I. Dunham

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. E. Scott

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • K. J. Ashcroft

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. L. Atkinson

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • K. Aubin

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • D. M. Beare

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • G. Bethel

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • N. Brady

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. C. Brook

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • D. C. Burford

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • W. D. Burrill

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. Burrows

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. P. Butler

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. Carder

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. J. Catanese

    (Children's Hospital-BACPAC Resources)

  • C. M. Clee

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. M. Clegg

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • V. Cobley

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. J. Coffey

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. G. Cole

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. E. Collins

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. S. Conquer

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • R. A. Cooper

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • K. M. Culley

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • E. Dawson

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • F. L. Dearden

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • R. M. Durbin

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • P. J. de Jong

    (Children's Hospital-BACPAC Resources)

  • P. D. Dhami

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • M. E. Earthrowl

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. A. Edwards

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • R. S. Evans

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. J. Gillson

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. Ghori

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • L. Green

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • R. Gwilliam

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • K. S. Halls

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. Hammond

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • G. L. Harper

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • R. W. Heathcott

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. L. Holden

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • E. Holloway

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • B. L. Hopkins

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • P. J. Howard

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • G. R. Howell

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • E. J. Huckle

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. Hughes

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • P. J. Hunt

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. E. Hunt

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • M. Izmajlowicz

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. A. Jones

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. S. Joseph

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • G. Laird

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. F. Langford

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • M. H. Lehvaslaiho

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • M. A. Leversha

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • O. T. McCann

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • L. M. McDonald

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. McDowall

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • G. L. Maslen

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • D. Mistry

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • N. K. Moschonas

    (University of Crete and Institute of Molecular Biology and Biotechnology)

  • V. Neocleous

    (Neurogenetic Laboratory, The Cyprus Institute of Neurology and Genetics)

  • D. M. Pearson

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • K. J. Phillips

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • K. M. Porter

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. R. Prathalingam

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • Y. H. Ramsey

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. A. Ranby

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. M. Rice

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. Rogers

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • L. J. Rogers

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • T. Sarafidou

    (University of Crete and Institute of Molecular Biology and Biotechnology)

  • D. J. Scott

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • G. J. Sharp

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. J. Shaw-Smith

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • L. J. Smink

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. Soderlund

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • E. C. Sotheran

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • H. E. Steingruber

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • J. E. Sulston

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. Taylor

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • R. G. Taylor

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. A. Thorpe

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • E. Tinsley

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • G. L. Warry

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • A. Whittaker

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • P. Whittaker

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • S. H. Williams

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • T. E. Wilmer

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • R. Wooster

    (The Sanger Centre, Wellcome Trust Genome Campus)

  • C. L. Wright

    (The Sanger Centre, Wellcome Trust Genome Campus)

Abstract

We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.

Suggested Citation

  • D. R. Bentley & P. Deloukas & A. Dunham & L. French & S. G. Gregory & S. J. Humphray & A. J. Mungall & M. T. Ross & N. P. Carter & I. Dunham & C. E. Scott & K. J. Ashcroft & A. L. Atkinson & K. Aubin , 2001. "The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X," Nature, Nature, vol. 409(6822), pages 942-943, February.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6822:d:10.1038_35057165
    DOI: 10.1038/35057165
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