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Computational comparison of two draft sequences of the human genome

Author

Listed:
  • John Aach

    (The Lipper Center for Computational Genetics)

  • Martha L. Bulyk

    (Program in Biophysics)

  • George M. Church

    (The Lipper Center for Computational Genetics
    Department of Genetics)

  • Jason Comander

    (Pathology, Harvard Medical School)

  • Adnan Derti

    (The Lipper Center for Computational Genetics
    Department of Genetics
    Program in Bioinformatics, Boston University)

  • Jay Shendure

    (The Lipper Center for Computational Genetics)

Abstract

We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. We look at a number of features of the sequences, including sequence gaps, continuity, consistency between the two sequences and patterns of DNA-binding protein motifs.

Suggested Citation

  • John Aach & Martha L. Bulyk & George M. Church & Jason Comander & Adnan Derti & Jay Shendure, 2001. "Computational comparison of two draft sequences of the human genome," Nature, Nature, vol. 409(6822), pages 856-859, February.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6822:d:10.1038_35057055
    DOI: 10.1038/35057055
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