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Expressing the human genome

Author

Listed:
  • Rossella Tupler

    (Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School
    Biologia Generale e Genetica Medica, Università degli Studi di Pavia)

  • Giovanni Perini

    (University of Bologna)

  • Michael R. Green

    (Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School)

Abstract

We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation. A plethora of potential new factors are implicated by sequence in nuclear gene expression, revealing a substantial but selective increase in complexity compared with Drosophila melanogaster and Caenorhabditis elegans. Although the raw genomic information has limitations, its availability offers new experimental approaches for studying gene expression.

Suggested Citation

  • Rossella Tupler & Giovanni Perini & Michael R. Green, 2001. "Expressing the human genome," Nature, Nature, vol. 409(6822), pages 832-833, February.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6822:d:10.1038_35057011
    DOI: 10.1038/35057011
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    Cited by:

    1. Dolgonosov, B.M., 2010. "On the reasons of hyperbolic growth in the biological and human world systems," Ecological Modelling, Elsevier, vol. 221(13), pages 1702-1709.
    2. Yan Li & Qianmin Wang & Yanhui Xu & Ze Li, 2024. "Structures of co-transcriptional RNA capping enzymes on paused transcription complex," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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