IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v409y2001i6819d10.1038_35054000.html
   My bibliography  Save this article

The architecture of active zone material at the frog's neuromuscular junction

Author

Listed:
  • Mark L. Harlow

    (Stanford University School of Medicine)

  • David Ress

    (Stanford University School of Medicine)

  • Arne Stoschek

    (Stanford University School of Medicine)

  • Robert M. Marshall

    (Stanford University School of Medicine)

  • Uel J. McMahan

    (Stanford University School of Medicine)

Abstract

Active zone material at the nervous system's synapses is situated next to synaptic vesicles that are docked at the presynaptic plasma membrane, and calcium channels that are anchored in the membrane. Here we use electron microscope tomography to show the arrangement and associations of structural components of this compact organelle at a model synapse, the frog's neuromuscular junction. Our findings indicate that the active zone material helps to dock the vesicles and anchor the channels, and that its architecture provides both a particular spatial relationship and a structural linkage between them. The structural linkage may include proteins that mediate the calcium-triggered exocytosis of neurotransmitter by the synaptic vesicles during synaptic transmission.

Suggested Citation

  • Mark L. Harlow & David Ress & Arne Stoschek & Robert M. Marshall & Uel J. McMahan, 2001. "The architecture of active zone material at the frog's neuromuscular junction," Nature, Nature, vol. 409(6819), pages 479-484, January.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6819:d:10.1038_35054000
    DOI: 10.1038/35054000
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35054000
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35054000?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:409:y:2001:i:6819:d:10.1038_35054000. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.