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Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

Author

Listed:
  • Alyson E. Fournier

    (Yale University School of Medicine)

  • Tadzia GrandPre

    (Yale University School of Medicine)

  • Stephen M. Strittmatter

    (Yale University School of Medicine)

Abstract

Nogo has been identified as a component of the central nervous system (CNS) myelin that prevents axonal regeneration in the adult vertebrate CNS. Analysis of Nogo-A has shown that an axon-inhibiting domain of 66 amino acids is expressed at the extracellular surface and at the endoplasmic reticulum lumen of transfected cells and oligodendrocytes1. The acidic amino terminus of Nogo-A is detected at the cytosolic face of cellular membranes1 and may contribute to inhibition of axon regeneration at sites of oligodendrocyte injury2,3. Here we show that the extracellular domain of Nogo (Nogo-66) inhibits axonal extension, but does not alter non-neuronal cell morphology. In contrast, a multivalent form of the N terminus of Nogo-A affects the morphology of both neurons and other cell types. Here we identify a brain-specific, leucine-rich-repeat protein with high affinity for soluble Nogo-66. Cleavage of the Nogo-66 receptor and other glycophosphatidylinositol-linked proteins from axonal surfaces renders neurons insensitive to Nogo-66. Nogo-66 receptor expression is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Disruption of the interaction between Nogo-66 and its receptor provides the potential for enhanced recovery after human CNS injury.

Suggested Citation

  • Alyson E. Fournier & Tadzia GrandPre & Stephen M. Strittmatter, 2001. "Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration," Nature, Nature, vol. 409(6818), pages 341-346, January.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6818:d:10.1038_35053072
    DOI: 10.1038/35053072
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    Cited by:

    1. Fereshteh Pourabdolhossein & Sabah Mozafari & Ghislaine Morvan-Dubois & Javad Mirnajafi-Zadeh & Alejandra Lopez-Juarez & Jacqueline Pierre-Simons & Barbara A Demeneix & Mohammad Javan, 2014. "Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-13, September.
    2. M. Clement & J. L. Forbester & M. Marsden & P. Sabberwal & M. S. Sommerville & D. Wellington & S. Dimonte & S. Clare & K. Harcourt & Z. Yin & L. Nobre & R. Antrobus & B. Jin & M. Chen & S. Makvandi-Ne, 2022. "IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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