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Enabling the chemistry of life

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  • Christopher Walsh

    (Biological Chemistry and Molecular Pharmacology Department Harvard Medical School)

Abstract

Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in product-determining reactions. Many enzymes are members of families that carry out related chemical transformations and offer opportunities for directed in vitro evolution, to tailor catalytic properties to particular functions.

Suggested Citation

  • Christopher Walsh, 2001. "Enabling the chemistry of life," Nature, Nature, vol. 409(6817), pages 226-231, January.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6817:d:10.1038_35051697
    DOI: 10.1038/35051697
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