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DNA methylation in Drosophila melanogaster

Author

Listed:
  • Frank Lyko

    (Whitehead Institute for Biomedical Research)

  • Bernard H. Ramsahoye

    (John Hughes Bennett Laboratory, University of Edinburgh, Western General Hospital)

  • Rudolf Jaenisch

    (Whitehead Institute for Biomedical Research
    Massachusetts Institute of Technology)

Abstract

Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an exception1,2,3,4, but now the evidence points to the existence of a functional DNA-methylation system in Drosophila as well5,6,7,9. Here we show that DNA is methylated, but that Drosophila genomic methylation is restricted to the early stages of embryonic development.

Suggested Citation

  • Frank Lyko & Bernard H. Ramsahoye & Rudolf Jaenisch, 2000. "DNA methylation in Drosophila melanogaster," Nature, Nature, vol. 408(6812), pages 538-540, November.
  • Handle: RePEc:nat:nature:v:408:y:2000:i:6812:d:10.1038_35046205
    DOI: 10.1038/35046205
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