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Development of a preventive vaccine for Ebola virus infection in primates

Author

Listed:
  • Nancy J. Sullivan

    (Vaccine Research Center, National Institutes of Health)

  • Anthony Sanchez

    (Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Pierre E. Rollin

    (Special Pathogens Branch, Centers for Disease Control and Prevention)

  • Zhi-yong Yang

    (Vaccine Research Center, National Institutes of Health)

  • Gary J. Nabel

    (Vaccine Research Center, National Institutes of Health)

Abstract

Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date1,2. Its rapid progression allows little opportunity to develop natural immunity, and there is currently no effective anti-viral therapy. Therefore, vaccination offers a promising intervention to prevent infection and limit spread. Here we describe a highly effective vaccine strategy for Ebola virus infection in non-human primates. A combination of DNA immunization and boosting with adenoviral vectors that encode viral proteins generated cellular and humoral immunity in cynomolgus macaques. Challenge with a lethal dose of the highly pathogenic, wild-type, 1976 Mayinga strain of Ebola Zaire virus resulted in uniform infection in controls, who progressed to a moribund state and death in less than one week. In contrast, all vaccinated animals were asymptomatic for more than six months, with no detectable virus after the initial challenge. These findings demonstrate that it is possible to develop a preventive vaccine against Ebola virus infection in primates.

Suggested Citation

  • Nancy J. Sullivan & Anthony Sanchez & Pierre E. Rollin & Zhi-yong Yang & Gary J. Nabel, 2000. "Development of a preventive vaccine for Ebola virus infection in primates," Nature, Nature, vol. 408(6812), pages 605-609, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6812:d:10.1038_35046108
    DOI: 10.1038/35046108
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    Cited by:

    1. Jade Mitchell & Kara Dean & Charles Haas, 2020. "Ebola Virus Dose Response Model for Aerosolized Exposures: Insights from Primate Data," Risk Analysis, John Wiley & Sons, vol. 40(11), pages 2390-2398, November.
    2. Nicholas V. Olijnyk, 2015. "An algorithmic historiography of the Ebola research specialty: mapping the science behind Ebola," Scientometrics, Springer;Akadémiai Kiadó, vol. 105(1), pages 623-643, October.
    3. Jeffrey E. Harris, 2021. "The Repeated Setbacks of HIV Vaccine Development Laid the Groundwork for SARS-CoV-2 Vaccines," NBER Working Papers 28587, National Bureau of Economic Research, Inc.
    4. Dokuyucu, Mustafa Ali & Dutta, Hemen, 2020. "A fractional order model for Ebola Virus with the new Caputo fractional derivative without singular kernel," Chaos, Solitons & Fractals, Elsevier, vol. 134(C).

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