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The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts

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  • Chian-Yu Peng

    (Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254)

  • Laurina Manning

    (Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254)

  • Roger Albertson

    (Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254)

  • Chris Q. Doe

    (Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254)

Abstract

Drosophila neuroblasts are a model system for studying asymmetric cell division: they divide unequally to produce an apical neuroblast and a basal ganglion mother cell that differ in size, mitotic activity and developmental potential. During neuroblast mitosis, an apical protein complex orients the mitotic spindle and targets determinants of cell fate to the basal cortex1, but the mechanism of each process is unknown. Here we show that the tumour-suppressor genes lethal giant larvae (lgl) and discs large (dlg) regulate basal protein targeting, but not apical complex formation or spindle orientation, in both embryonic and larval neuroblasts. Dlg protein is apically enriched and is required for maintaining cortical localization of Lgl protein. Basal protein targeting requires microfilament and myosin function, yet the lgl phenotype is strongly suppressed by reducing levels of myosin II. We conclude that Dlg and Lgl promote, and myosin II inhibits, actomyosin-dependent basal protein targeting in neuroblasts.

Suggested Citation

  • Chian-Yu Peng & Laurina Manning & Roger Albertson & Chris Q. Doe, 2000. "The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts," Nature, Nature, vol. 408(6812), pages 596-600, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6812:d:10.1038_35046094
    DOI: 10.1038/35046094
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