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Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast

Author

Listed:
  • Tomokazu Ohshiro

    (CREST, Japan Science and Technology Corporation
    Institute of Development, Aging, and Cancer, Tohoku University)

  • Takako Yagami

    (CREST, Japan Science and Technology Corporation)

  • Chuan Zhang

    (CREST, Japan Science and Technology Corporation
    Institute of Development, Aging, and Cancer, Tohoku University)

  • Fumio Matsuzaki

    (CREST, Japan Science and Technology Corporation
    Cell Asymmetry Group, RIKEN Center for Developmental Biology
    Institute of Development, Aging, and Cancer, Tohoku University)

Abstract

Cellular diversity during development arises in part from asymmetric divisions, which generate two distinct cells by transmitting localized determinants from a progenitor cell into one daughter cell. In Drosophila, neuroblasts undergo typical asymmetric divisions to produce another neuroblast and a ganglion mother cell1,2. At mitosis, neural fate determinants, including Prospero and Numb, localize to the basal cortex3,4, from which the ganglion mother cell buds off; Inscuteable and Bazooka, which regulate spindle orientation, localize apically5,6,7,8. Here we show that a tumour-suppressor protein, Lethal giant larvae (Lgl)9, is essential for asymmetric cortical localization of all basal determinants in mitotic neuroblasts, and is therefore indispensable for neural fate decisions. Lgl, which itself is uniformly cortical, interacts with several types of Myosin to localize the determinants. Another tumour-suppressor protein, Lethal discs large (Dlg)10, participates in this process by regulating the localization of Lgl. The localization of the apical components is unaffected in lgl or dlg mutants. Thus, Lgl and Dlg act in a common process that differentially mediates cortical protein targeting in mitotic neuroblasts, and that creates intrinsic differences between daughter cells.

Suggested Citation

  • Tomokazu Ohshiro & Takako Yagami & Chuan Zhang & Fumio Matsuzaki, 2000. "Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast," Nature, Nature, vol. 408(6812), pages 593-596, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6812:d:10.1038_35046087
    DOI: 10.1038/35046087
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    Cited by:

    1. Delfina M. Romero & Karine Poirier & Richard Belvindrah & Imane Moutkine & Anne Houllier & Anne-Gaëlle LeMoing & Florence Petit & Anne Boland & Stephan C. Collins & Mariano Soiza-Reilly & Binnaz Yalci, 2022. "Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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