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In search of the tumour-suppressor functions of BRCA1 and BRCA2

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  • Ralph Scully

    (The Dana-Farber Cancer Institute and the Harvard Medical School)

  • David M. Livingston

    (The Dana-Farber Cancer Institute and the Harvard Medical School)

Abstract

Hereditary breast and ovarian cancer syndromes can be caused by loss-of-function germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref. 1). Each gene product interacts with recombination/DNA repair proteins in pathways that participate in preserving intact chromosome structure. However, it is unclear to what extent such functions specifically suppress breast and ovarian cancer. Here we analyse what is known of BRCA gene function and highlight some unanswered questions in the field.

Suggested Citation

  • Ralph Scully & David M. Livingston, 2000. "In search of the tumour-suppressor functions of BRCA1 and BRCA2," Nature, Nature, vol. 408(6811), pages 429-432, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6811:d:10.1038_35044000
    DOI: 10.1038/35044000
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    Cited by:

    1. Tanay Thakar & Ashna Dhoonmoon & Joshua Straka & Emily M. Schleicher & Claudia M. Nicolae & George-Lucian Moldovan, 2022. "Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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