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Why do we age?

Author

Listed:
  • Thomas B. L. Kirkwood

    (University of Newcastle Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne)

  • Steven N. Austad

    (University of Idaho)

Abstract

The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic factors that influence longevity and age-associated diseases.

Suggested Citation

  • Thomas B. L. Kirkwood & Steven N. Austad, 2000. "Why do we age?," Nature, Nature, vol. 408(6809), pages 233-238, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6809:d:10.1038_35041682
    DOI: 10.1038/35041682
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    Citations

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    Cited by:

    1. Paul G Shiels & Liane M McGlynn & Alan MacIntyre & Paul C D Johnson & G David Batty & Harry Burns & Jonathan Cavanagh & Kevin A Deans & Ian Ford & Alex McConnachie & Agnes McGinty & Jennifer S McLean , 2011. "Accelerated Telomere Attrition Is Associated with Relative Household Income, Diet and Inflammation in the pSoBid Cohort," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-7, July.
    2. Heijdra, Ben J. & Romp, Ward E., 2009. "Human capital formation and macroeconomic performance in an ageing small open economy," Journal of Economic Dynamics and Control, Elsevier, vol. 33(3), pages 725-744, March.
    3. Strulik, Holger, 2008. "Geography, health, and the pace of demo-economic development," Journal of Development Economics, Elsevier, vol. 86(1), pages 61-75, April.
    4. Xinyue Zhang & Xiaolu Gao & Danxian Wu & Zening Xu & Hongjie Wang, 2021. "The Role of Big Data in Aging and Older People’s Health Research: A Systematic Review and Ecological Framework," Sustainability, MDPI, vol. 13(21), pages 1-19, October.
    5. Steve Horvath & Joshua Zhang & Amin Haghani & Ake T. Lu & Zhe Fei, 2024. "Fundamental equations linking methylation dynamics to maximum lifespan in mammals," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Katherine E Overman & Daniel M Choi & Kawai Leung & Joshua W Shaevitz & Gordon J Berman, 2022. "Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster," PLOS Computational Biology, Public Library of Science, vol. 18(2), pages 1-19, February.
    7. Miguel Portela & Paul Schweinzer, 2013. "The Parental Co-Immunization Hypothesis," CESifo Working Paper Series 4472, CESifo.
    8. Cesarini, David & Lindqvist, Erik & Wallace, Björn, 2007. "Maternal Longevity and the Sex of Offspring: Evidence from Pre-Industrial Sweden," SSE/EFI Working Paper Series in Economics and Finance 651, Stockholm School of Economics.
    9. Jean-Philippe Coppé & Christopher K Patil & Francis Rodier & Yu Sun & Denise P Muñoz & Joshua Goldstein & Peter S Nelson & Pierre-Yves Desprez & Judith Campisi, 2008. "Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor," PLOS Biology, Public Library of Science, vol. 6(12), pages 1-1, December.
    10. Pernille Sarup & Simon Metz Mariendal Pedersen & Niels Chr Nielsen & Anders Malmendal & Volker Loeschcke, 2012. "The Metabolic Profile of Long-Lived Drosophila melanogaster," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-11, October.

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