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Regenerating the damaged central nervous system

Author

Listed:
  • Philip J. Horner

    (The Laboratory of Genetics)

  • Fred H. Gage

    (The Laboratory of Genetics)

Abstract

It is self-evident that the adult mammalian brain and spinal cord do not regenerate after injury, but recent discoveries have forced a reconsideration of this accepted principle. Advances in our understanding of how the brain develops have provided a rough blueprint for how we may bring about regeneration in the damaged brain. Studies in developmental neurobiology, intracellular signalling and neuroimmunology are bringing the regeneration field closer to success. Notwithstanding these advances, clear and indisputable evidence for adult functional regeneration remains to be shown.

Suggested Citation

  • Philip J. Horner & Fred H. Gage, 2000. "Regenerating the damaged central nervous system," Nature, Nature, vol. 407(6807), pages 963-970, October.
  • Handle: RePEc:nat:nature:v:407:y:2000:i:6807:d:10.1038_35039559
    DOI: 10.1038/35039559
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