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Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

Author

Listed:
  • Cheol-Hee Kim

    (Laboratory of Molecular Genetics, NICHD)

  • Takaya Oda

    (Genetics and Molecular Biology Branch, NHGRI, NIH)

  • Motoyuki Itoh

    (Laboratory of Molecular Genetics, NICHD)

  • Di Jiang

    (Laboratory of Molecular Genetics, NICHD)

  • Kristin Bruk Artinger

    (Harvard Medical School)

  • Settara C. Chandrasekharappa

    (Genetics and Molecular Biology Branch, NHGRI, NIH)

  • Wolfgang Driever

    (University of Freiburg, Institute for Zoology)

  • Ajay B. Chitnis

    (Laboratory of Molecular Genetics, NICHD)

Abstract

The vertebrate organizer can induce a complete body axis when transplanted to the ventral side of a host embryo1 by virtue of its distinct head and trunk inducing properties. Wingless/Wnt antagonists secreted by the organizer have been identified as head inducers2,3,4. Their ectopic expression can promote head formation, whereas ectopic activation of Wnt signalling during early gastrulation blocks head formation5,6,7. These observations suggest that the ability of head inducers to inhibit Wnt signalling during formation of anterior structures is what distinguishes them from trunk inducers that permit the operation of posteriorizing Wnt signals8. Here we describe the zebrafish headless (hdl) mutant and show that its severe head defects are due to a mutation in T-cell factor-3 (Tcf3), a member of the Tcf/Lef family9,10. Loss of Tcf3 function in the hdl mutant reveals that hdl represses Wnt target genes. We provide genetic evidence that a component of the Wnt signalling pathway is essential in vertebrate head formation and patterning.

Suggested Citation

  • Cheol-Hee Kim & Takaya Oda & Motoyuki Itoh & Di Jiang & Kristin Bruk Artinger & Settara C. Chandrasekharappa & Wolfgang Driever & Ajay B. Chitnis, 2000. "Repressor activity of Headless/Tcf3 is essential for vertebrate head formation," Nature, Nature, vol. 407(6806), pages 913-916, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6806:d:10.1038_35038097
    DOI: 10.1038/35038097
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    Cited by:

    1. Saurabh J. Pradhan & Puli Chandramouli Reddy & Michael Smutny & Ankita Sharma & Keisuke Sako & Meghana S. Oak & Rini Shah & Mrinmoy Pal & Ojas Deshpande & Greg Dsilva & Yin Tang & Rakesh Mishra & Giri, 2021. "Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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