IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v407y2000i6805d10.1038_35037739.html
   My bibliography  Save this article

Apoptosis in the nervous system

Author

Listed:
  • Junying Yuan

    (Children's Hospital)

  • Bruce A. Yankner

    (Harvard Medical School)

Abstract

Neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. The principal molecular components of the apoptosis programme in neurons include Apaf-1 (apoptotic protease-activating factor 1) and proteins of the Bcl-2 and caspase families. Neurotrophins regulate neuronal apoptosis through the action of critical protein kinase cascades, such as the phosphoinositide 3-kinase/Akt and mitogen-activated protein kinase pathways. Similar cell-death-signalling pathways might be activated in neurodegenerative diseases by abnormal protein structures, such as amyloid fibrils in Alzheimer's disease. Elucidation of the cell death machinery in neurons promises to provide multiple points of therapeutic intervention in neurodegenerative diseases.

Suggested Citation

  • Junying Yuan & Bruce A. Yankner, 2000. "Apoptosis in the nervous system," Nature, Nature, vol. 407(6805), pages 802-809, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037739
    DOI: 10.1038/35037739
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35037739
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35037739?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yue Feng & Hang Zhu & Xu Zhang & Xuxia Wang & Fuqiang Xu & Huiru Tang & Chaohui Ye & Maili Liu, 2015. "NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-14, October.
    2. Yue Huang & Xuezhi Sun & Guangshu Hu, 2011. "An integrated genetics approach for identifying protein signal pathways of Alzheimer's disease," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 14(04), pages 371-378.
    3. Anne Eugster & Anna Lorenc & Martin Kotrulev & Yogesh Kamra & Manisha Goel & Katja Steinberg-Bains & Shereen Sabbah & Sevina Dietz & Ezio Bonifacio & Mark Peakman & Iria Gomez-Tourino, 2024. "Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037739. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.