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Apoptosis in development

Author

Listed:
  • Pascal Meier

    (Signal Transduction Laboratory, Imperial Cancer Research Fund
    Institute of Cancer Research, Chester Beatty Laboratories)

  • Andrew Finch

    (UCSF Cancer Center)

  • Gerard Evan

    (UCSF Cancer Center)

Abstract

Essential to the construction, maintenance and repair of tissues is the ability to induce suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency. Study of three principal organisms — the nematode, fruitfly and mouse — indicate that cell suicide is implemented through the activation of an evolutionarily conserved molecular programme intrinsic to all metazoan cells. Dysfunctions in the regulation or execution of cell suicide are implicated in a wide range of developmental abnormalities and diseases.

Suggested Citation

  • Pascal Meier & Andrew Finch & Gerard Evan, 2000. "Apoptosis in development," Nature, Nature, vol. 407(6805), pages 796-801, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037734
    DOI: 10.1038/35037734
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    Cited by:

    1. Ao Di & Yun Wu & Mindong Chen & Dongyang Nie & Xinlei Ge, 2020. "Chemical Characterization of Seasonal PM 2.5 Samples and Their Cytotoxicity in Human Lung Epithelial Cells (A549)," IJERPH, MDPI, vol. 17(12), pages 1-13, June.
    2. Kenneth L Ho & Heather A Harrington, 2010. "Bistability in Apoptosis by Receptor Clustering," PLOS Computational Biology, Public Library of Science, vol. 6(10), pages 1-9, October.
    3. Maxim Kuznetsov & Andrey Kolobov, 2023. "Agent-Based Model for Studying the Effects of Solid Stress and Nutrient Supply on Tumor Growth," Mathematics, MDPI, vol. 11(8), pages 1-23, April.

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