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Corpse clearance defines the meaning of cell death

Author

Listed:
  • John Savill

    (Program in Cell Biology, National Jewish Medical and Research Center)

  • Valerie Fadok

    (Program in Cell Biology, National Jewish Medical and Research Center)

Abstract

While philosophers seek the meaning of life, cell biologists are becoming ever more interested in the meaning of death. Apoptosis marks unwanted cells with 'eat me' signals that direct recognition, engulfment and degradation by phagocytes. Far from being the end of the story, these clearance events allow scavenger cells to confer meaning upon cell death. But if the phagocytic 'spin doctors' receive or transmit the wrong messages, trouble ensues.

Suggested Citation

  • John Savill & Valerie Fadok, 2000. "Corpse clearance defines the meaning of cell death," Nature, Nature, vol. 407(6805), pages 784-788, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037722
    DOI: 10.1038/35037722
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    Cited by:

    1. Tatiana Baumuratova & Simona Dobre & Thierry Bastogne & Thomas Sauter, 2013. "Switch of Sensitivity Dynamics Revealed with DyGloSA Toolbox for Dynamical Global Sensitivity Analysis as an Early Warning for System's Critical Transition," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-12, December.
    2. D. Rysanek & Z. Sladek & V. Babak & D. Vasickova & M. Hubackova, 2006. "Spontaneous and induced cytolysis of leukocytes from bovine mammary gland in the course of cultivation in vitro - the correlation with neutrophil granulocytes apoptosis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 51(5), pages 265-277.

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