IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v407y2000i6805d10.1038_35037619.html
   My bibliography  Save this article

The complete sequence of the mucosal pathogen Ureaplasma urealyticum

Author

Listed:
  • John I. Glass

    (University of Alabama at Birmingham
    Infectious Diseases Research and Clinical Investigation, Eli Lilly and Company)

  • Elliot J. Lefkowitz

    (University of Alabama at Birmingham)

  • Jennifer S. Glass

    (University of Alabama at Birmingham
    Infectious Diseases Research and Clinical Investigation, Eli Lilly and Company)

  • Cheryl R. Heiner

    (Advanced Center for Genomic Technology, Perkin-Elmer Corporation
    Celera Genomics, PE Corporation)

  • Ellson Y. Chen

    (Advanced Center for Genomic Technology, Perkin-Elmer Corporation
    Celera Genomics, PE Corporation)

  • Gail H. Cassell

    (University of Alabama at Birmingham
    Infectious Diseases Research and Clinical Investigation, Eli Lilly and Company)

Abstract

The comparison of the genomes of two very closely related human mucosal pathogens, Mycoplasma genitalium and Mycoplasma pneumoniae, has helped define the essential functions of a self-replicating minimal cell, as well as what constitutes a mycoplasma. Here we report the complete sequence of a more distant phylogenetic relative of those bacteria, Ureaplasma urealyticum (parvum biovar), which is also a mucosal pathogen of humans. It is the third mycoplasma to be sequenced, and has the smallest sequenced prokaryotic genome except for M. genitalium. Although the U. urealyticum genome is similar to the two sequenced mycoplasma genomes1,2, features make this organism unique among mycoplasmas and all bacteria. Almost all ATP synthesis is the result of urea hydrolysis, which generates an energy-producing electrochemical gradient. Some highly conserved eubacterial enzymes appear not to be encoded by U. urealyticum, including the cell-division protein FtsZ, chaperonins GroES and GroEL, and ribonucleoside-diphosphate reductase. U. urealyticum has six closely related iron transporters, which apparently arose through gene duplication, suggesting that it has a kind of respiration system not present in other small genome bacteria The genome is only 25.5% G+C in nucleotide content, and the G+C content of individual genes may predict how essential those genes are to ureaplasma survival.

Suggested Citation

  • John I. Glass & Elliot J. Lefkowitz & Jennifer S. Glass & Cheryl R. Heiner & Ellson Y. Chen & Gail H. Cassell, 2000. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum," Nature, Nature, vol. 407(6805), pages 757-762, October.
  • Handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037619
    DOI: 10.1038/35037619
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35037619
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/35037619?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alexandra Moura & Michael A Savageau & Rui Alves, 2013. "Relative Amino Acid Composition Signatures of Organisms and Environments," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-9, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:407:y:2000:i:6805:d:10.1038_35037619. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.