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A vertebrate globin expressed in the brain

Author

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  • Thorsten Burmester

    (Institutes of Zoology,)

  • Bettina Weich

    (Molecular Genetics, Biosafety Research and Consulting)

  • Sigrid Reinhardt

    (Johannes Gutenberg University Mainz)

  • Thomas Hankeln

    (Molecular Genetics, Biosafety Research and Consulting)

Abstract

Haemoglobins and myoglobins constitute related protein families that function in oxygen transport and storage in humans and other vertebrates1,2. Here we report the identification of a third globin type in man and mouse. This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 ≈ 2 torr). Analogous to myoglobin, neuroglobin may increase the availability of oxygen to brain tissue. The human neuroglobin gene (NGB), located on chromosome 14q24, has a unique exon–intron structure. Neuroglobin represents a distinct protein family that diverged early in metazoan evolution, probably before the Protostomia/Deuterostomia split.

Suggested Citation

  • Thorsten Burmester & Bettina Weich & Sigrid Reinhardt & Thomas Hankeln, 2000. "A vertebrate globin expressed in the brain," Nature, Nature, vol. 407(6803), pages 520-523, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6803:d:10.1038_35035093
    DOI: 10.1038/35035093
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    Cited by:

    1. Elizabeth Zoneff & Yi Wang & Colin Jackson & Oliver Smith & Serena Duchi & Carmine Onofrillo & Brooke Farrugia & Simon E. Moulton & Richard Williams & Clare Parish & David R. Nisbet & Lilith M. Caball, 2024. "Controlled oxygen delivery to power tissue regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Y. Wang & E. R. Zoneff & J. W. Thomas & N. Hong & L. L. Tan & D. J. McGillivray & A. W. Perriman & K. C. L. Law & L. H. Thompson & N. Moriarty & C. L. Parish & R. J. Williams & C. J. Jackson & D. R. N, 2023. "Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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