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RNA polymerase II elongation through chromatin

Author

Listed:
  • George Orphanides

    (Zeneca Central Toxicology Laboratory)

  • Danny Reinberg

    (Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School)

Abstract

The machinery that transcribes protein-coding genes in eukaryotic cells must contend with repressive chromatin structures in order to find its target DNA sequences. Diverse arrays of proteins modify the structure of chromatin at gene promoters to help transcriptional regulatory proteins access their DNA recognition sites. The way in which disruption of chromatin structure at a promoter is transmitted through a whole gene has not been defined. Recent breakthroughs suggest that the passage of an RNA polymerase through a gene is coupled to mechanisms that propagate the breakdown of chromatin.

Suggested Citation

  • George Orphanides & Danny Reinberg, 2000. "RNA polymerase II elongation through chromatin," Nature, Nature, vol. 407(6803), pages 471-476, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6803:d:10.1038_35035000
    DOI: 10.1038/35035000
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