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Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

Author

Listed:
  • Todd M. Allen

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • David H. O'Connor

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • Peicheng Jing

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • John L. Dzuris

    (Epimmune)

  • Bianca R. Mothé

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • Thorsten U. Vogel

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • Ed Dunphy

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • Max E. Liebl

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • Carol Emerson

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • Nancy Wilson

    (Wisconsin Regional Primate Research Center, University of Wisconsin)

  • Kevin J. Kunstman

    (Northwestern University Medical School)

  • Xiaochi Wang

    (Emory Vaccine Center, Emory University School of Medicine, G211 Rollins Research Building)

  • David B. Allison

    (St. Luke’s/Roosevelt Hospital, Obesity Research Center)

  • Austin L. Hughes

    (401 Coker Life Sciences, University of South Carolina)

  • Ronald C. Desrosiers

    (New England Regional Primate Research Center)

  • John D. Altman

    (Emory Vaccine Center, Emory University School of Medicine, G211 Rollins Research Building)

  • Steven M. Wolinsky

    (Northwestern University Medical School)

  • Alessandro Sette

    (Epimmune)

  • David I. Watkins

    (Wisconsin Regional Primate Research Center, University of Wisconsin
    Dept. of Pathology and Laboratory Medicine, University of Wisconsin)

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections are characterized by early peaks of viraemia that decline as strong cellular immune responses develop1,2. Although it has been shown that virus-specific CD8-positive cytotoxic T lymphocytes (CTLs) exert selective pressure during HIV and SIV infection3,4,5,6,7,8,9,10,11, the data have been controversial12,13. Here we show that Tat-specific CD8-positive T-lymphocyte responses select for new viral escape variants during the acute phase of infection. We sequenced the entire virus immediately after the acute phase, and found that amino-acid replacements accumulated primarily in Tat CTL epitopes. This implies that Tat-specific CTLs may be significantly involved in controlling wild-type virus replication, and suggests that responses against viral proteins that are expressed early during the viral life cycle might be attractive targets for HIV vaccine development.

Suggested Citation

  • Todd M. Allen & David H. O'Connor & Peicheng Jing & John L. Dzuris & Bianca R. Mothé & Thorsten U. Vogel & Ed Dunphy & Max E. Liebl & Carol Emerson & Nancy Wilson & Kevin J. Kunstman & Xiaochi Wang & , 2000. "Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia," Nature, Nature, vol. 407(6802), pages 386-390, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6802:d:10.1038_35030124
    DOI: 10.1038/35030124
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    Cited by:

    1. James M Billingsley & Premeela A Rajakumar & Michelle A Connole & Nadine C Salisch & Sama Adnan & Yury V Kuzmichev & Henoch S Hong & R Keith Reeves & Hyung-joo Kang & Wenjun Li & Qingsheng Li & Ashley, 2015. "Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling," PLOS Pathogens, Public Library of Science, vol. 11(3), pages 1-23, March.

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