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Thrombin signalling and protease-activated receptors

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  • Shaun R. Coughlin

    (University of California at San Francisco)

Abstract

How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

Suggested Citation

  • Shaun R. Coughlin, 2000. "Thrombin signalling and protease-activated receptors," Nature, Nature, vol. 407(6801), pages 258-264, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6801:d:10.1038_35025229
    DOI: 10.1038/35025229
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    Cited by:

    1. Carlos E. Bravo-Iñiguez & Jason R. Fritz & Shilpa Shukla & Susmita Sarangi & Dane A. Thompson & Seema G. Amin & Tea Tsaava & Saher Chaudhry & Sara P. Valentino & Hannah B. Hoffman & Catherine W. Imoss, 2023. "Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Sonu Kumar & Boris I Ratnikov & Marat D Kazanov & Jeffrey W Smith & Piotr Cieplak, 2015. "CleavPredict: A Platform for Reasoning about Matrix Metalloproteinases Proteolytic Events," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-19, May.

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