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A genetic blueprint for cardiac development

Author

Listed:
  • Deepak Srivastava

    (Southwestern Medical Center at Dallas
    University of Texas, Southwestern Medical Center at Dallas)

  • Eric N. Olson

    (Southwestern Medical Center at Dallas)

Abstract

Congenital heart disease is the leading non-infectious cause of death in children. It is becoming increasingly clear that many cardiac abnormalities once thought to have multifactorial aetiologies are attributable to mutations in developmental control genes. The consequences of these mutations can be manifest at birth as life-threatening cardiac malformations or later as more subtle cardiac abnormalities. Understanding the genetic underpinnings of cardiac development has important implications not only for understanding congenital heart disease, but also for the possibility of cardiac repair through genetic reprogramming of non-cardiac cells to a cardiogenic fate.

Suggested Citation

  • Deepak Srivastava & Eric N. Olson, 2000. "A genetic blueprint for cardiac development," Nature, Nature, vol. 407(6801), pages 221-226, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6801:d:10.1038_35025190
    DOI: 10.1038/35025190
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    Cited by:

    1. Nadeem Ul Nazeer & Mohammad Akbar Bhat & Bilal Rah & Gh Rasool Bhat & Shadil Ibrahim Wani & Adfar Yousuf & Abdul Majeed Dar & Dil Afroze, 2022. "Mutational Assessment in NKX2-5 and ACTC1 Genes in Patients with Congenital Cardiac Septal Defect (CCSD) from Ethnic Kashmiri Population," IJERPH, MDPI, vol. 19(16), pages 1-12, August.

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