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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Author

Listed:
  • Bert Hobmayer

    (Darmstadt University of Technology)

  • Fabian Rentzsch

    (Darmstadt University of Technology)

  • Kerstin Kuhn

    (Darmstadt University of Technology)

  • Christoph M. Happel

    (Darmstadt University of Technology)

  • Christoph Cramer von Laue

    (Darmstadt University of Technology)

  • Petra Snyder

    (Darmstadt University of Technology)

  • Ute Rothbächer

    (Laboratoire de Genetique et Physiologie du Developpement, IBDM, Campus de Luminy)

  • Thomas W. Holstein

    (Darmstadt University of Technology)

Abstract

Members of the Wnt/wingless family of secreted proteins act as short-range inducers and long-range organizers during axis formation, organogenesis and tumorigenesis in many developing tissues1. Wnt signalling pathways are conserved in nematodes, insects and vertebrates2. Despite its developmental significance, the evolutionary origin of Wnt signalling is unclear. Here we describe the molecular characterization of members of the Wnt signalling pathway—Wnt, Dishevelled, GSK3, β-Catenin and Tcf/Lef—in Hydra, a member of the evolutionarily old metazoan phylum Cnidaria. Wnt and Tcf are expressed in the putative Hydra head organizer, the upper part of the hypostome. Wnt, β-Catenin and Tcf are transcriptionally upregulated when head organizers are established early in bud formation and head regeneration. Wnt and Tcf expression domains also define head organizers created by de novo pattern formation in aggregates. Our results indicate that Wnt signalling may be involved in axis formation in Hydra and support the idea that it was central in the evolution of axial differentiation in early multicellular animals.

Suggested Citation

  • Bert Hobmayer & Fabian Rentzsch & Kerstin Kuhn & Christoph M. Happel & Christoph Cramer von Laue & Petra Snyder & Ute Rothbächer & Thomas W. Holstein, 2000. "WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra," Nature, Nature, vol. 407(6801), pages 186-189, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6801:d:10.1038_35025063
    DOI: 10.1038/35025063
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    Cited by:

    1. Chakraborty, Priya & Jolly, Mohit Kumar & Roy, Ushasi & Ghosh, Sayantari, 2023. "Spatio-temporal pattern formation due to host-circuit interplay in gene expression dynamics," Chaos, Solitons & Fractals, Elsevier, vol. 167(C).
    2. Felix Brinkmann & Moritz Mercker & Thomas Richter & Anna Marciniak-Czochra, 2018. "Post-Turing tissue pattern formation: Advent of mechanochemistry," PLOS Computational Biology, Public Library of Science, vol. 14(7), pages 1-21, July.
    3. Moritz Mercker & Dirk Hartmann & Anna Marciniak-Czochra, 2013. "A Mechanochemical Model for Embryonic Pattern Formation: Coupling Tissue Mechanics and Morphogen Expression," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-6, December.

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