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Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

Author

Listed:
  • James A. McNew

    (Rice University)

  • Francesco Parlati
  • Ryouichi Fukuda

    (University of Tokyo)

  • Robert J. Johnston
  • Keren Paz
  • Fabienne Paumet
  • Thomas H. Söllner
  • James E. Rothman

Abstract

Membrane-enveloped vesicles travel among the compartments of the cytoplasm of eukaryotic cells, delivering their specific cargo to programmed locations by membrane fusion. The pairing of vesicle v-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) with target membrane t-SNAREs has a central role in intracellular membrane fusion. We have tested all of the potential v-SNAREs encoded in the yeast genome for their capacity to trigger fusion by partnering with t-SNAREs that mark the Golgi, the vacuole and the plasma membrane. Here we find that, to a marked degree, the pattern of membrane flow in the cell is encoded and recapitulated by its isolated SNARE proteins, as predicted by the SNARE hypothesis.

Suggested Citation

  • James A. McNew & Francesco Parlati & Ryouichi Fukuda & Robert J. Johnston & Keren Paz & Fabienne Paumet & Thomas H. Söllner & James E. Rothman, 2000. "Compartmental specificity of cellular membrane fusion encoded in SNARE proteins," Nature, Nature, vol. 407(6801), pages 153-159, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6801:d:10.1038_35025000
    DOI: 10.1038/35025000
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    Cited by:

    1. Bhavya R. Bhaskar & Laxmi Yadav & Malavika Sriram & Kinjal Sanghrajka & Mayank Gupta & Boby K. V & Rohith K. Nellikka & Debasis Das, 2024. "Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates fusion pore fate at the release site," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Yue Chen & Jia Liu & Seogchan Kang & Dongsheng Wei & Yani Fan & Meichun Xiang & Xingzhong Liu, 2023. "A palisade-shaped membrane reservoir is required for rapid ring cell inflation in Drechslerella dactyloides," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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