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Microtubule motors in mitosis

Author

Listed:
  • David J. Sharp

    (Section of Molecular and Cellular Biology, University of California-Davis)

  • Gregory C. Rogers

    (Section of Molecular and Cellular Biology, University of California-Davis)

  • Jonathan M. Scholey

    (Section of Molecular and Cellular Biology, University of California-Davis)

Abstract

The mitotic spindle uses microtubule-based motor proteins to assemble itself and to segregate sister chromatids. It is becoming clear that motors invoke several distinct mechanisms to generate the forces that drive mitosis. Moreover, in carrying out its function, the spindle appears to pass through a series of transient steady-state structures, each established by a delicate balance of forces generated by multiple complementary and antagonistic motors. Transitions from one steady state to the next can occur when a change in the activity of a subset of mitotic motors tips the balance.

Suggested Citation

  • David J. Sharp & Gregory C. Rogers & Jonathan M. Scholey, 2000. "Microtubule motors in mitosis," Nature, Nature, vol. 407(6800), pages 41-47, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6800:d:10.1038_35024000
    DOI: 10.1038/35024000
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    Cited by:

    1. Yinzhi Zhao & Paul Toselli & Wande Li, 2012. "Microtubules as a Critical Target for Arsenic Toxicity in Lung Cells in Vitro and in Vivo," IJERPH, MDPI, vol. 9(2), pages 1-22, February.
    2. Ana M Rojas & Anna Santamaria & Rainer Malik & Thomas Skøt Jensen & Roman Körner & Ian Morilla & David de Juan & Martin Krallinger & Daniel Aaen Hansen & Robert Hoffmann & Jonathan Lees & Adam Reid & , 2012. "Uncovering the Molecular Machinery of the Human Spindle—An Integration of Wet and Dry Systems Biology," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-16, March.

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