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SLAM (CDw150) is a cellular receptor for measles virus

Author

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  • Hironobu Tatsuo

    (Faculty of Medicine, Kyushu University)

  • Nobuyuki Ono

    (Faculty of Medicine, Kyushu University)

  • Kotaro Tanaka

    (Faculty of Medicine, Kyushu University)

  • Yusuke Yanagi

    (Faculty of Medicine, Kyushu University)

Abstract

Measles virus continues to be a major killer of children, claiming roughly one million lives a year1. Measles virus infection causes profound immunosuppression, which makes measles patients susceptible to secondary infections accounting for high morbidity and mortality2. The Edmonston strain of measles virus, and vaccine strains derived from it, use as a cellular receptor human CD46 (refs 3, 4), which is expressed on all nucleated cells; however, most clinical isolates of measles virus cannot use CD46 as a receptor5. Here we show that human SLAM (signalling lymphocyte-activation molecule; also known as CDw150), a recently discovered membrane glycoprotein expressed on some T and B cells6, is a cellular receptor for measles virus, including the Edmonston strain. Transfection with a human SLAM complementary DNA enables non-susceptible cell lines to bind measles virus, support measles virus replication and develop cytopathic effects. The distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus. The identification of SLAM as a receptor for measles virus opens the way to a better understanding of the pathogenesis of measles virus infection, especially the immunosuppression induced by measles virus.

Suggested Citation

  • Hironobu Tatsuo & Nobuyuki Ono & Kotaro Tanaka & Yusuke Yanagi, 2000. "SLAM (CDw150) is a cellular receptor for measles virus," Nature, Nature, vol. 406(6798), pages 893-897, August.
    • Handle: RePEc:nat:nature:v:406:y:2000:i:6798:d:10.1038_35022579
    DOI: 10.1038/35022579
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    Cited by:

    1. Koich Saeki & Akira Sasaki, 2018. "The role of spatial heterogeneity in the evolution of local and global infections of viruses," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-20, January.
    2. Olivier Reynard & Claudia Gonzalez & Claire Dumont & Mathieu Iampietro & Marion Ferren & Sandrine Guellec & Lajoie Laurie & Cyrille Mathieu & Gabrielle Carpentier & Georges Roseau & Francesca T. Bovie, 2022. "Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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