IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v406y2000i6792d10.1038_35018092.html
   My bibliography  Save this article

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

Author

Listed:
  • Erik Kupperman

    (Departments of Biochemistry and Biophysics and)

  • Songzhu An

    (University of California San Francisco)

  • Nick Osborne

    (Departments of Biochemistry and Biophysics and)

  • Steven Waldron

    (Departments of Biochemistry and Biophysics and)

  • Didier Y. R. Stainier

    (Departments of Biochemistry and Biophysics and)

Abstract

Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation1,2 specifically affects the migration of the heart precursors to the midline. We found that mutant cells transplanted into a wild-type embryo migrate normally and that wild-type cells in a mutant embryo fail to migrate, suggesting that mil may be involved in generating an environment permissive for migration. We isolated mil by positional cloning and show that it encodes a member of the lysosphingolipid G-protein-coupled receptor family. We also show that sphingosine-1-phosphate is a ligand for Mil, and that it activates several downstream signalling events that are not activated by the mutant alleles. These data reveal a new role for lysosphingolipids in regulating cell migration during vertebrate development and provide the first molecular clues into the fusion of the bilateral heart primordia during organogenesis of the heart.

Suggested Citation

  • Erik Kupperman & Songzhu An & Nick Osborne & Steven Waldron & Didier Y. R. Stainier, 2000. "A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development," Nature, Nature, vol. 406(6792), pages 192-195, July.
    • Handle: RePEc:nat:nature:v:406:y:2000:i:6792:d:10.1038_35018092
    DOI: 10.1038/35018092
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35018092
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35018092?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:406:y:2000:i:6792:d:10.1038_35018092. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.