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Initiation of neural induction by FGF signalling before gastrulation

Author

Listed:
  • Andrea Streit

    (Department of Genetics and Development)

  • Alyson J. Berliner

    (Center for Neurobiology and Behavior, Columbia University)

  • Costis Papanayotou

    (Department of Genetics and Development)

  • Andrés Sirulnik

    (Department of Genetics and Development)

  • Claudio D. Stern

    (Department of Genetics and Development
    Center for Neurobiology and Behavior, Columbia University)

Abstract

During neural induction, the ‘organizer’ of the vertebrate embryo instructs neighbouring ectodermal cells to become nervous system rather than epidermis. This process is generally thought to occur around the mid-gastrula stage of embryogenesis1. Here we report the isolation of ERNI, an early response gene to signals from the organizer (Hensen's node). Using ERNI as a marker, we present evidence that neural induction begins before gastrulation—much earlier in development than previously thought. We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction.

Suggested Citation

  • Andrea Streit & Alyson J. Berliner & Costis Papanayotou & Andrés Sirulnik & Claudio D. Stern, 2000. "Initiation of neural induction by FGF signalling before gastrulation," Nature, Nature, vol. 406(6791), pages 74-78, July.
    • Handle: RePEc:nat:nature:v:406:y:2000:i:6791:d:10.1038_35017617
    DOI: 10.1038/35017617
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    Cited by:

    1. Anthony J. Asmar & Shaun R. Abrams & Jenny Hsin & Jason C. Collins & Rita M. Yazejian & Youmei Wu & Jean Cho & Andrew D. Doyle & Samhitha Cinthala & Marleen Simon & Richard H. Jaarsveld & David B. Bec, 2023. "A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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