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Stable germline transformation of the malaria mosquito Anopheles stephensi

Author

Listed:
  • Flaminia Catteruccia

    (Imperial College of Science, Technology and Medicine)

  • Tony Nolan

    (Imperial College of Science, Technology and Medicine)

  • Thanasis G. Loukeris

    (European Molecular Biology Laboratory)

  • Claudia Blass

    (European Molecular Biology Laboratory)

  • Charalambos Savakis

    (Institute of Molecular Biology and Biotechnology, Research Centre of Crete, Foundation for Research and Technology Hellas)

  • Fotis C. Kafatos

    (European Molecular Biology Laboratory)

  • Andrea Crisanti

    (Imperial College of Science, Technology and Medicine)

Abstract

Anopheline mosquito species are obligatory vectors for human malaria, an infectious disease that affects hundreds of millions of people living in tropical and subtropical countries. The lack of a suitable gene transfer technology for these mosquitoes has hampered the molecular genetic analysis of their physiology, including the molecular interactions between the vector and the malaria parasite. Here we show that a transposon, based on the Minos element1 and bearing exogenous DNA, can integrate efficiently and stably into the germ line of the human malaria vector Anopheles stephensi , through a transposase-mediated process.

Suggested Citation

  • Flaminia Catteruccia & Tony Nolan & Thanasis G. Loukeris & Claudia Blass & Charalambos Savakis & Fotis C. Kafatos & Andrea Crisanti, 2000. "Stable germline transformation of the malaria mosquito Anopheles stephensi," Nature, Nature, vol. 405(6789), pages 959-962, June.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6789:d:10.1038_35016096
    DOI: 10.1038/35016096
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    Cited by:

    1. Vanessa M. Macias & Johanna R. Ohm & Jason L. Rasgon, 2017. "Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?," IJERPH, MDPI, vol. 14(9), pages 1-30, September.

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