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Pharmacogenetics and the practice of medicine

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  • Allen D. Roses

    (Genetics Directorate, Glaxo Wellcome plc
    Duke University Medical Center)

Abstract

“If it were not for the great variability among individuals medicine might as well be a science and not an art.” The thoughts of Sir William Osler in 1892 reflect the view of medicine over the past 100 years. The role of physicians in making the necessary judgements about the medicines that they prescribe is often referred to as an art, reflecting the lack of objective data available to make decisions that are tailored to individual patients. Just over a hundred years later we are on the verge of being able to identify inherited differences between individuals which can predict each patient's response to a medicine. This ability will have far-reaching benefits in the discovery, development and delivery of medicines. Sir William Osler, if he were alive today, would be re-considering his view of medicine as an art not a science.

Suggested Citation

  • Allen D. Roses, 2000. "Pharmacogenetics and the practice of medicine," Nature, Nature, vol. 405(6788), pages 857-865, June.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6788:d:10.1038_35015728
    DOI: 10.1038/35015728
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    Cited by:

    1. Dragojlovic, Nick & Kopac, Nicola & Borle, Kennedy & Tandun, Rachel & Salmasi, Shahrzad & Ellis, Ursula & Birch, Patricia & Adam, Shelin & Friedman, Jan M. & Elliott, Alison M. & Lynd, Larry D., 2021. "Utilization and uptake of clinical genetics services in high-income countries: A scoping review," Health Policy, Elsevier, vol. 125(7), pages 877-887.
    2. Boon, Wouter & Moors, Ellen, 2008. "Exploring emerging technologies using metaphors - A study of orphan drugs and pharmacogenomics," Social Science & Medicine, Elsevier, vol. 66(9), pages 1915-1927, May.
    3. Se Yoon Lee, 2022. "Bayesian Nonlinear Models for Repeated Measurement Data: An Overview, Implementation, and Applications," Mathematics, MDPI, vol. 10(6), pages 1-51, March.
    4. Michael V Holmes & Tina Shah & Christine Vickery & Liam Smeeth & Aroon D Hingorani & Juan P Casas, 2009. "Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic Studies," PLOS ONE, Public Library of Science, vol. 4(12), pages 1-14, December.
    5. Tutton, Richard, 2012. "Personalizing medicine: Futures present and past," Social Science & Medicine, Elsevier, vol. 75(10), pages 1721-1728.
    6. Robert S. Poulson & Gary L. Gadbury & David B. Allison, 2012. "Treatment Heterogeneity and Individual Qualitative Interaction," The American Statistician, Taylor & Francis Journals, vol. 66(1), pages 16-24, February.
    7. Hopkins, Michael M. & Martin, Paul A. & Nightingale, Paul & Kraft, Alison & Mahdi, Surya, 2007. "The myth of the biotech revolution: An assessment of technological, clinical and organisational change," Research Policy, Elsevier, vol. 36(4), pages 566-589, May.

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