IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v405y2000i6788d10.1038_35015500.html
   My bibliography  Save this article

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

Author

Listed:
  • Michael Oelgeschläger

    (Howard Hughes Medical Institute and Department of Biological Chemistry University of California)

  • Juan Larraín

    (Howard Hughes Medical Institute and Department of Biological Chemistry University of California)

  • Douglas Geissert

    (Howard Hughes Medical Institute and Department of Biological Chemistry University of California)

  • Eddy M. De Robertis

    (Howard Hughes Medical Institute and Department of Biological Chemistry University of California)

Abstract

Dorsal–ventral patterning in vertebrate and Drosophila embryos requires a conserved system of extracellular proteins to generate a positional information gradient. The components involved include bone morphogenetic proteins (BMP/Dpp), a BMP antagonist (Chordin/Short gastrulation; Chd/Sog) and a secreted metalloproteinase (Xolloid/Tolloid) that cleaves Chd/Sog. Here we describe Xenopus Twisted gastrulation (xTsg), another member of this signalling pathway. xTsg is expressed ventrally as part of the BMP-4 synexpression group and encodes a secreted BMP-binding protein that is a BMP signalling agonist. The data suggest a molecular mechanism by which xTsg dislodges latent BMPs bound to Chordin BMP-binding fragments generated by Xolloid cleavage, providing a permissive signal that allows high BMP signalling in the embryo. Drosophila Tsg also binds BMPs and is expressed dorsally, supporting the proposal that the dorsal–ventral axis was inverted in the course of animal evolution.

Suggested Citation

  • Michael Oelgeschläger & Juan Larraín & Douglas Geissert & Eddy M. De Robertis, 2000. "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling," Nature, Nature, vol. 405(6788), pages 757-763, June.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6788:d:10.1038_35015500
    DOI: 10.1038/35015500
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35015500
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35015500?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tomas Malinauskas & Gareth Moore & Amalie F. Rudolf & Holly Eggington & Hayley L. Belnoue-Davis & Kamel El Omari & Samuel C. Griffiths & Rachel E. Woolley & Ramona Duman & Armin Wagner & Simon J. Leed, 2024. "Molecular mechanism of BMP signal control by Twisted gastrulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:405:y:2000:i:6788:d:10.1038_35015500. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.