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Silence across the border

Author

Listed:
  • Wolf Reik

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute)

  • Adele Murrell

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute)

Abstract

Imprinted genes, such as the closely linked genesH19 and Igf2, are expressed from either the maternal or the paternal chromosome, but not both. A newly discovered mechanism for ‘silencing’ the Igf2 gene on the maternal chromosome involves an ‘insulator’ region found upstream of H19.

Suggested Citation

  • Wolf Reik & Adele Murrell, 2000. "Silence across the border," Nature, Nature, vol. 405(6785), pages 408-409, May.
  • Handle: RePEc:nat:nature:v:405:y:2000:i:6785:d:10.1038_35013178
    DOI: 10.1038/35013178
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