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Transfection of cells by immunoporation

Author

Listed:
  • Lale Bildirici

    (University of Essex)

  • Patricia Smith

    (University of Essex)

  • Christos Tzavelas

    (University of Essex)

  • Elina Horefti

    (University of Essex)

  • David Rickwood

    (University of Essex)

Abstract

Cell transfection is now a central technique in molecular biology and an essential prerequisite for gene therapy. Here we describe how beads coated with antibodies and bound to specific cell-surface transmembrane proteins can create holes in cells when the beads are removed, allowing transfection of the cells with DNA or other macromolecules. This unique targeted transfection of cells by immunoporation is very efficient and results in minimal cell death.

Suggested Citation

  • Lale Bildirici & Patricia Smith & Christos Tzavelas & Elina Horefti & David Rickwood, 2000. "Transfection of cells by immunoporation," Nature, Nature, vol. 405(6784), pages 298-298, May.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6784:d:10.1038_35012701
    DOI: 10.1038/35012701
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