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Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

Author

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  • Dwight E. Bergles

    (Vollum Institute, L474, Oregon Health Sciences University)

  • J. David B. Roberts

    (MRC Anatomical Neuropharmacology Unit, University of Oxford)

  • Peter Somogyi

    (MRC Anatomical Neuropharmacology Unit, University of Oxford)

  • Craig E. Jahr

    (Vollum Institute, L474, Oregon Health Sciences University)

Abstract

Fast excitatory neurotransmission in the central nervous system occurs at specialized synaptic junctions between neurons, where a high concentration of glutamate directly activates receptor channels. Low-affinity AMPA (α-amino-3-hydroxy-5-methyl isoxazole propionic acid) and kainate glutamate receptors are also expressed by some glial cells1, including oligodendrocyte precursor cells (OPCs). However, the conditions that result in activation of glutamate receptors on these non-neuronal cells are not known. Here we report that stimulation of excitatory axons in the hippocampus elicits inward currents in OPCs that are mediated by AMPA receptors. The quantal nature of these responses and their rapid kinetics indicate that they are produced by the exocytosis of vesicles filled with glutamate directly opposite these receptors. Some of these AMPA receptors are permeable to calcium ions, providing a link between axonal activity and internal calcium levels in OPCs. Electron microscopic analysis revealed that vesicle-filled axon terminals make synaptic junctions with the processes of OPCs in both the young and adult hippocampus. These results demonstrate the existence of a rapid signalling pathway from pyramidal neurons to OPCs in the mammalian hippocampus that is mediated by excitatory, glutamatergic synapses.

Suggested Citation

  • Dwight E. Bergles & J. David B. Roberts & Peter Somogyi & Craig E. Jahr, 2000. "Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus," Nature, Nature, vol. 405(6783), pages 187-191, May.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6783:d:10.1038_35012083
    DOI: 10.1038/35012083
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    Cited by:

    1. Golia Shafiei & Ben D. Fulcher & Bradley Voytek & Theodore D. Satterthwaite & Sylvain Baillet & Bratislav Misic, 2023. "Neurophysiological signatures of cortical micro-architecture," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Takahiro Shimizu & Stuart G. Nayar & Matthew Swire & Yi Jiang & Matthew Grist & Malte Kaller & Cassandra Sampaio Baptista & David M. Bannerman & Heidi Johansen-Berg & Katsutoshi Ogasawara & Koujiro To, 2023. "Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Chang Hoon Cho & Ilana Vasilisa Deyneko & Dylann Cordova-Martinez & Juan Vazquez & Anne S. Maguire & Jenny R. Diaz & Abigail U. Carbonell & Jaafar O. Tindi & Min-Hui Cui & Roman Fleysher & Sophie Molh, 2023. "ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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