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Transgenerational mutation by radiation

Author

Listed:
  • Yuri E. Dubrova

    (University of Leicester
    N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences)

  • Mark Plumb

    (Medical Research Council Radiation and Genome Stability Unit)

  • Bruno Gutierrez

    (University of Leicester)

  • Emma Boulton

    (Medical Research Council Radiation and Genome Stability Unit)

  • Alec J. Jeffreys

    (University of Leicester)

Abstract

Parental exposure to ionizing radiation increases the frequency of germline mutations detectable in the next generation1. Parental exposure can also increase the rate of mutation in somatic cells2,3 and confer a predisposition to cancer4,5,6 in offspring, suggesting that there could be an indirect effect of radiation on somatic genome stability that is transmissible through the germ line of the irradiated parents. We have found that this indirect effect extends to the germ line of unexposed first-generation offspring in mice, as revealed by an increased instability of repeat-DNA sequences in their descendants.

Suggested Citation

  • Yuri E. Dubrova & Mark Plumb & Bruno Gutierrez & Emma Boulton & Alec J. Jeffreys, 2000. "Transgenerational mutation by radiation," Nature, Nature, vol. 405(6782), pages 37-37, May.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6782:d:10.1038_35011135
    DOI: 10.1038/35011135
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    Cited by:

    1. Mark S. Pearce & Heather O. Dickinson & Murray Aitkin & Louise Parker, 2002. "Still-births among the offspring of male radiation workers at the Sellafield nuclear reprocessing plant: detailed results and statistical aspects," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 165(3), pages 523-548.

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