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Medicinal strategies in the treatment of obesity

Author

Listed:
  • George A. Bray
  • Louis A. Tartaglia

    (Millennium Pharmaceuticals Inc.)

Abstract

When prevention fails, medicinal treatment of obesity may become a necessity. Any strategic medicinal development must recognize that obesity is a chronic, stigmatized and costly disease that is increasing in prevalence. Because obesity can rarely be cured, treatment strategies are effective only as long as they are used, and combined therapy may be more effective than monotherapy. For a drug to have significant impact on body weight it must ultimately reduce energy intake, increase energy expenditure, or both. Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion.

Suggested Citation

  • George A. Bray & Louis A. Tartaglia, 2000. "Medicinal strategies in the treatment of obesity," Nature, Nature, vol. 404(6778), pages 672-677, April.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6778:d:10.1038_35007544
    DOI: 10.1038/35007544
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    Cited by:

    1. Smith, Trenton G, 2002. "Obesity and Nature's Thumbprint: How Modern Waistlines Can Inform Economic Theory," University of California at Santa Barbara, Economics Working Paper Series qt31g1m028, Department of Economics, UC Santa Barbara.
    2. Gracia-Arnaiz, Mabel, 2017. "Taking measures in times of crisis: The political economy of obesity prevention in Spain," Food Policy, Elsevier, vol. 68(C), pages 65-76.
    3. Changhyun Roh & Min-Kyoung Park & Hee-June Shin & Insub Kim & Jin Kyu Kim & Uhee Jung, 2012. "Anti-Obesity Effect of Nepetae spica Extract in High-Fat Mice," Agriculture, MDPI, vol. 2(3), pages 1-7, August.

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