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Towards a molecular understanding of adaptive thermogenesis

Author

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  • Bradford B. Lowell

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Bruce M. Spiegelman

    (Dana-Farber Cancer Institute, Harvard Medical School)

Abstract

Obesity results when energy intake exceeds energy expenditure. Naturally occurring genetic mutations, as well as ablative lesions, have shown that the brain regulates both aspects of energy balance and that abnormalities in energy expenditure contribute to the development of obesity. Energy can be expended by performing work or producing heat (thermogenesis). Adaptive thermogenesis, or the regulated production of heat, is influenced by environmental temperature and diet. Mitochondria, the organelles that convert food to carbon dioxide, water and ATP, are fundamental in mediating effects on energy dissipation. Recently, there have been significant advances in understanding the molecular regulation of energy expenditure in mitochondria and the mechanisms of transcriptional control of mitochondrial genes. Here we explore these developments in relation to classical physiological views of adaptive thermogenesis.

Suggested Citation

  • Bradford B. Lowell & Bruce M. Spiegelman, 2000. "Towards a molecular understanding of adaptive thermogenesis," Nature, Nature, vol. 404(6778), pages 652-660, April.
  • Handle: RePEc:nat:nature:v:404:y:2000:i:6778:d:10.1038_35007527
    DOI: 10.1038/35007527
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