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Non-haemolytic β-amino-acid oligomers

Author

Listed:
  • Emilie A. Porter

    (University of Wisconsin)

  • Xifang Wang

    (University of Wisconsin)

  • Hee-Seung Lee

    (University of Wisconsin)

  • Bernard Weisblum

    (University of Wisconsin)

  • Samuel H. Gellman

    (University of Wisconsin)

Abstract

Pathogenic bacteria are becoming increasingly resistant to common antibiotics, stimulating an intensive search for new ones. Knowing that a class of medium-sized peptides (magainins1) are widely used by host organisms as a defence against microbial invasion2, we developed a β-amino-acid oligomer (β-peptide) that mimics these natural antibiotics and tested it for antimicrobial activity. We find not only that the activity of our β-peptide is comparable to that of a magainin derivative but also that it is effective against four bacterial species, including two pathogens that are resistant to common antibiotics.

Suggested Citation

  • Emilie A. Porter & Xifang Wang & Hee-Seung Lee & Bernard Weisblum & Samuel H. Gellman, 2000. "Non-haemolytic β-amino-acid oligomers," Nature, Nature, vol. 404(6778), pages 565-565, April.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6778:d:10.1038_35007145
    DOI: 10.1038/35007145
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    Cited by:

    1. Kamal el Battioui & Sohini Chakraborty & András Wacha & Dániel Molnár & Mayra Quemé-Peña & Imola Cs. Szigyártó & Csenge Lilla Szabó & Andrea Bodor & Kata Horváti & Gergő Gyulai & Szilvia Bősze & Judit, 2024. "In situ captured antibacterial action of membrane-incising peptide lamellae," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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