IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v404y2000i6776d10.1038_35006097.html
   My bibliography  Save this article

Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

Author

Listed:
  • Long Gu

    (Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School)

  • Susan Tseng

    (Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School)

  • Renée M. Horner

    (Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School)

  • Carmen Tam

    (Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School)

  • Massimo Loda

    (Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School)

  • Barrett J. Rollins

    (Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School)

Abstract

Activated T lymphocytes differentiate into effector cells tailored to meet disparate challenges to host integrity1. For example, type 1 and type 2 helper (TH1 and TH2) cells secrete cytokines that enhance cell-mediated and humoral immunity, respectively. The chemokine monocyte chemoattractant protein-1 (MCP-1) can stimulate interleukin-4 production2 and its overexpression is associated with defects in cell-mediated immunity3, indicating that it might be involved in TH2 polarization. Here we show that MCP-1-deficient mice are unable to mount TH2 responses. Lymph node cells from immunized MCP-1-/- mice synthesize extremely low levels of interleukin-4, interleukin-5 and interleukin-10, but normal amounts of interferon-γ and interleukin-2. Consequently, these mice do not accomplish the immunoglobulin subclass switch that is characteristic of TH2 responses and are resistant to Leishmania major. These effects are direct rather than due to abnormal cell migration, because the trafficking of naive T cells is undisturbed in MCP-1-/- mice despite the presence of MCP-1-expressing cells in secondary lymphoid organs of wild-type mice. Thus, MCP-1 influences both innate immunity, through effects on monocytes, and adaptive immunity, through control of T helper cell polarization.

Suggested Citation

  • Long Gu & Susan Tseng & Renée M. Horner & Carmen Tam & Massimo Loda & Barrett J. Rollins, 2000. "Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1," Nature, Nature, vol. 404(6776), pages 407-411, March.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6776:d:10.1038_35006097
    DOI: 10.1038/35006097
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35006097
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35006097?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Maria Klasson & Magnus Lindberg & Eva Särndahl & Håkan Westberg & Ing-Liss Bryngelsson & Kedeye Tuerxun & Alexander Persson, 2021. "Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt. Effects of high and low calcium growth conditions," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-19, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:404:y:2000:i:6776:d:10.1038_35006097. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.