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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Author

Listed:
  • Koichi Akashi

    (Stanford University School of Medicine
    Dana-Farber Cancer Institute)

  • David Traver

    (Stanford University School of Medicine)

  • Toshihiro Miyamoto

    (Stanford University School of Medicine)

  • Irving L. Weissman

    (Stanford University School of Medicine)

Abstract

Haematopoietic stem cells give rise to progeny that progressively lose self-renewal capacity and become restricted to one lineage1,2. The points at which haematopoietic stem cell-derived progenitors commit to each of the various lineages remain mostly unknown. We have identified a clonogenic common lymphoid progenitor that can differentiate into T, B and natural killer cells but not myeloid cells3. Here we report the prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Common myeloid progenitors give rise to either megakaryocyte/erythrocyte or granulocyte/macrophage progenitors. Purified progenitors were used to provide a first-pass expression profile of various haematopoiesis-related genes. We propose that the common lymphoid progenitor and common myeloid progenitor populations reflect the earliest branch points between the lymphoid and myeloid lineages, and that the commitment of common myeloid progenitors to either the megakaryocyte/erythrocyte or the granulocyte/macrophage lineages are mutually exclusive events.

Suggested Citation

  • Koichi Akashi & David Traver & Toshihiro Miyamoto & Irving L. Weissman, 2000. "A clonogenic common myeloid progenitor that gives rise to all myeloid lineages," Nature, Nature, vol. 404(6774), pages 193-197, March.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6774:d:10.1038_35004599
    DOI: 10.1038/35004599
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    Cited by:

    1. Ritsuko Nakai & Takafumi Yokota & Masahiro Tokunaga & Mikiro Takaishi & Tomomasa Yokomizo & Takao Sudo & Henyun Shi & Yoshiaki Yasumizu & Daisuke Okuzaki & Chikara Kokubu & Sachiyo Tanaka & Katsuyoshi, 2024. "A newly identified gene Ahed plays essential roles in murine haematopoiesis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Linghua Zhou & Yong Shen & Libo Jiang & Danni Yin & Jingxin Guo & Hui Zheng & Hao Sun & Rongling Wu & Yunqian Guo, 2015. "Systems Mapping for Hematopoietic Progenitor Cell Heterogeneity," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-18, May.
    3. Bin Zhang & Dandan Zhao & Fang Chen & David Frankhouser & Huafeng Wang & Khyatiben V. Pathak & Lei Dong & Anakaren Torres & Krystine Garcia-Mansfield & Yi Zhang & Dinh Hoa Hoang & Min-Hsuan Chen & Shu, 2023. "Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Kiyoka Saito & Mark Garde & Terumasa Umemoto & Natsumi Miharada & Julia Sjöberg & Valgardur Sigurdsson & Haruki Shirozu & Shunsuke Kamei & Visnja Radulovic & Mitsuyoshi Suzuki & Satoshi Nakano & Stefa, 2024. "Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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