IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v403y2000i6771d10.1038_35001602.html
   My bibliography  Save this article

Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer

Author

Listed:
  • Michiru Nishita

    (National Institute for Basic Biology)

  • Minako K. Hashimoto

    (University of California)

  • Souichi Ogata

    (University of California)

  • Micheline N. Laurent

    (University of California
    California Institute of Technology)

  • Naoto Ueno

    (National Institute for Basic Biology)

  • Hiroshi Shibuya

    (National Institute for Basic Biology)

  • Ken W. Y. Cho

    (University of California)

Abstract

Members of the Wnt and TGF-β superfamilies regulate both cell fate and proliferation during development and tissue maintenance1,2,3. In the early amphibian embryo, the Wnt and TGF-β superfamily signalling cascades are required for the establishment of a dorsal signalling centre, Spemann's organizer4,5,6,7,8. Intracellular proteins of both pathways, upon activation, translocate to the nucleus to participate in transcription. Here we show that β-catenin and Lef1/Tcf, which are downstream components of the Wnt signalling cascade, form a complex with Smad4, an essential mediator of signals initiated by members of the TGF-β growth factor superfamily. In Xenopus, this interaction directly and synergistically affects expression of the twin (Xtwn) gene during formation of the organizer. This is, to our knowledge, the first demonstration of a physical interaction between TGF-β and Wnt signalling components in vivo.

Suggested Citation

  • Michiru Nishita & Minako K. Hashimoto & Souichi Ogata & Micheline N. Laurent & Naoto Ueno & Hiroshi Shibuya & Ken W. Y. Cho, 2000. "Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer," Nature, Nature, vol. 403(6771), pages 781-785, February.
    • Handle: RePEc:nat:nature:v:403:y:2000:i:6771:d:10.1038_35001602
    DOI: 10.1038/35001602
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35001602
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35001602?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:403:y:2000:i:6771:d:10.1038_35001602. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.