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Inhibitor of neurite outgrowth in humans

Author

Listed:
  • Rabinder Prinjha

    (Department of Neuroscience Research)

  • Stephen E. Moore

    (Department of Neuroscience Research)

  • Mary Vinson

    (Department of Neuroscience Research)

  • Sian Blake

    (Department of Neuroscience Research)

  • Rachel Morrow

    (Department of Neuroscience Research)

  • Gary Christie

    (Department of Neuroscience Research)

  • David Michalovich

    (Departments of Neuroscience Research and Bioinformatics)

  • David L. Simmons

    (Department of Neuroscience Research)

  • Frank S. Walsh

    (Department of Neuroscience Research)

Abstract

Axons are generally believed to be incapable of regeneration in the adult central nervous system1,2. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin3,4,5, the insulating axon sheath. These molecules include proteoglycans6, myelin-associated glycoprotein3,5 and, in bovine brain, two proteins called Nogo7,8,9. We have used this bovine sequence to identify the human Nogo gene and have isolated complementary DNA clones encoding three different Nogo isoforms that are potent inhibitors of neurite outgrowth and which may help block the regeneration of the central nervous system in adults.

Suggested Citation

  • Rabinder Prinjha & Stephen E. Moore & Mary Vinson & Sian Blake & Rachel Morrow & Gary Christie & David Michalovich & David L. Simmons & Frank S. Walsh, 2000. "Inhibitor of neurite outgrowth in humans," Nature, Nature, vol. 403(6768), pages 383-384, January.
    • Handle: RePEc:nat:nature:v:403:y:2000:i:6768:d:10.1038_35000287
    DOI: 10.1038/35000287
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